Pathology 851 Practical Exam

7 March, 1997

Click an image to enlarge
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  1. The following slide is a histological section from a patient who has had a history of repeated infections with coliform bacteria. The section demonstrates
    A. normal transitional cell epithelium
    B. transitional cell carcinoma in-situ
    C. chronic inflammation within the lamina propria
    D. Bowen disease
    E. squamous metaplasia
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  2. The following slide is a histological section from a patient who emigrated from the Middle East. The section demonstrates
    A. calcification of the stroma
    B. remote infection by trematodes
    C. squamous cell carcinoma
    D. transitional cell carcinoma
    E. metaplasia
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  3. The following slide is a histological section from a patient who has a papillary lesion in his bladder. The section is consistent with
    A. transitional cell papilloma
    B. transitional cell carcinoma
    C. transitional hyperplasia
    D. chronic cystitis
    E. fibroepithelial polyp
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  4. The following slide is a histological section from a patient with a diffuse bladder lesion. It demonstrates
    A. low grade non-invasive papillary transitional cell carcinoma
    B. transitional cell carcinoma in-situ
    C. transitional cell hyperplasia
    D. chronic cystitis
    E. human papilloma virus infection
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  5. The following slide is a histological section from a testicle. It is:
    A. seminoma
    B. associated with an increased risk of germ cell tumor
    C. associated with a genotypic sex disorder
    D. glandular metaplasia
    E. cystic metaplasia
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  6. The following slide is a histological section from a testicle. The most likely diagnosis is
    A. seminoma
    B. acute inflammation secondary to mumps orchitis
    C. torsion testicle
    D. granulomatous orchitis
    E. eosinophilic orchitis
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  7. The following slide is a photograph of a testicle. It is
    A. most common germ cell tumor
    B. embryonal carcinoma
    C. lipoma
    D. lymphoma
    E. yolk sac carcinoma
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  8. The following slide is a histological section from a testicle. It illustrates
    A. giant cell carcinoma
    B. staining for alpha feto-protein
    C. staining for human chorionic gonadotrophin
    D. metastatic carcinoma
    E. prostate carcinoma
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  9. The following slide is a histological section from a patient who experienced difficulty in urination. It demonstrates
    A. proliferation of glands predominantly in the transition zone
    B. proliferation of glandular tissue leading to carcinoma
    C. infarction of glandular and stromal tissue
    D. granulomatous inflammation of the prostate
    E. adenocarcinoma of the prostate
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  10. The depicted histological section if stained with specific markers would display
    A. staining for basal cell specific keratin
    B. loss of staining for prostate specific antigen
    C. loss of staining for basal cell specific keratin
    D. staining for Human chorionic gonadatrophin
    E. staining for p53 oncogene
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  11. The tumor cells infiltrating between strands of connective tissue in the breast are the characteristic histologic feature of
    A. fibroadenoma
    B. invasive lobular carcinoma
    C. comedocarcinoma
    D. medullary carcinoma
    E. sclerosing adenosis
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  12. A 69 year old woman noticed a gradual enlargement of her abdomen. Surgery revealed a large cystic ovarian tumor with excresences on the internal surface of the cyst. The histological features of this lesion are seen on your slide. The most likely diagnosis is
    A. benign paraovarian cyst
    B. benign mucinous cyst
    C. choriocarcinoma
    D. serous papillary cystadenocarcinoma
    E. granulosa cell tumor
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  13. Each of the following are CORRECT regarding this lesion in the fallopian tube EXCEPT (infl. = inflammation)
    A. most common location is the peritoneal cavity
    B. most common symptom is abdominal pain
    C. common pathogenetic mechanism is infl. or endometriosis
    D. the endometrium undergoes decidualization
    E. rupture of fallopian tube is a life threatening complication
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  14. A cervical biopsy shows atypical cells in the epithelium and no evidence of epithelial maturation whatsoever. The most appropriate diagnosis is
    A. mild dysplasia
    B. severe dysplasia or carcinoma in situ
    C. CIN I
    D. squamous cell carcinoma
    E. microinvasive carcinoma
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  15. A solitary, discrete, freely movable 2.5 cm breast mass in a twenty-five year old nulliparous woman is detected. The histological features of this lesion are shown. The most likely diagnosis is
    A. fibroadenoma
    B. medullary carcinoma
    C. lobular carcinoma in situ
    D. fibrocystic disease
    E. abscess
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  16. Which of the following viruses plays an etiologic role in the development of this lesion in the cervix?
    A. human immunodeficiency virus
    B. herpes simplex virus
    C. epstein-Barr virus
    D. cytomegalovirus
    E. human papilloma virus
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  17. This is one of the most common benign germ cell tumors of the ovaries in premenopausal women. The best diagnosis is
    A. brenner tumor
    B. hilus cell tumor
    C. dermoid cyst
    D. mucinous cystadenoma
    E. dysgerminoma
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  18. This picture was taken from the ovary of a 29-year-old infertile woman with mutiple small dark red to brown lesions on her ovaries and fallopian tubes. The most likely diagnosis is
    A. brenner tumor
    B. endometriosis
    C. adenocarcinoma of the ovary
    D. krukenberg tumor
    E. tubo-ovarian abcesses
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  19. This picture is taken from the breast of a 35 year-old women with a questionable lump in her breast. The most likely diagnosis is
    A. infiltrating ductal carcinoma
    B. medullary carcinoma
    C. fibroadenoma
    D. lactational changes
    E. fibrocystic change
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  20. This hysterectomy specimen is taken from a 46-year-old woman because of severe vaginal bleeding. The most likely diagnosis is
    A. endometrial hyperplasia
    B. endometrial adenocarcinoma
    C. leimyosarcoma
    D. leiomyoma
    E. endometrial stromal tumor
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  21. The clinical condition shown in this photograph can be observed in all of the following disorders, EXCEPT
    A. Hemophilia A
    B. Hemophilia B
    C. vonWillebrand disease
    D. Thrombotic thrombocytopenia purpura
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  22. The abnormality observed in this peripheral blood smear is associated with
    A. iron deficiency anemia
    B. pernicious anemia
    C. aplastic anemia
    D. anemia of chronic disease
    E. autoimmune hemolytic anemia
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  23. This peripheral blood smears displays features most suggestive of
    A. thalassemia
    B. iron deficiency anemia
    C. megaloblastic anemia
    D. autoimmune hemolytic anemia
    E. sickle cell anemia
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  24. The red blood cells in this peripheral blood smear would be associated with which CBC report?
    A. MCV 82, hemoglobin 12.0 gm/dl
    B. MCV 92, hemoglobin 14.0 gm/dl
    C. MCV 65, hemoglobin 8.0 gm/dl
    D. MCV 80, hemoglobin14gm/dl
    E. MCV 65, hemoglobin14 gm/dl
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  25. This peripheral blood smear shows arrows pointing to red blood cells which represent
    A. microcytes
    B. spherocytes
    C. reticulocytes (polychromasia)
    D. schistocytes
    E. poikilocytes
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  26. This bone marrow biopsy is from a patient with pancytopenia. The best diagnosis is
    A. hemolytic anemia
    B. megaloblastic anemia
    C. sickle cell anemia
    D. aplastic anemia
    E. iron deficiency anemia
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  27. This peripheral blood smear demonstrates an abnormality termed
    A. anisocytosis
    B. poikilocytosis
    C. reticulocytosis
    D. rouleaux
    E. Megaloblastic maturation
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  28. The largest cell in the middle of the field in this bone marrow biopsy is involved in the synthesis of
    A. red blood cells
    B. granulocytes
    C. platelets
    D. lymphocytes
    E. monocytes
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  29. The histopathologic findings in this slide of a lymph node biopsy are diagnostic of
    A. NonHodgkin's lymphoma
    B. Hodgkin's disease
    C. Acute lymphoblastic lymphoma
    D. Langerhans histiocytosis
    E. reactive lymphadenapathy
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  30. The findings displayed in this peripheral blood smear are suggestive of
    A. acute myeloid leukemia
    B. chronic lymphocytic leukemia
    C. chronic myelogenous leukemia
    D. disseminated intravascular coagulation
    E. infectious mononucleosis
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  31. This smear of a bone marrow aspirate is representative of
    A. acute lymphoblastic leukemia
    B. chronic lymphocytic leukemia
    C. multiple myeloma
    D. nonHodgkin's lymphoma
    E. Langerhans histiocytosis
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  32. A patient presented with fatigue, and the peripheral smear displayed the findings on the slide. The most common associated disorder is
    A. thrombotic thrombocytopenic purpura
    B. disseminated intravascular coagulation
    C. gum hypertrophy
    D. hemarthrosis
    E. idiopathic thrombocytopenia purpura
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  33. A biopsy of a large abdominal mass is shown in this slide. The most likely diagnosis is
    A. Hodgkin's disease
    B. nonHodgkin's lymphoma, low grade
    C. Burkitt's lymphoma
    D. Langerhans histiocytosis
    E. acute myeloid leukemia
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  34. This peripheral blood smear is from a patient with fever and leukocytosis. In the diagnostic evaluation of this disorder, the most appropriate test to order is
    A. lymph node biopsy
    B. reticulocyte count
    C. bone marrow biopsy
    D. hemoglobin electrophoresis
    E. serum iron studies
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  35. This cell was observed in the bone marrow of a patient with pancytopenia, splenomegaly and a bone marrow aspiration "dry tap". The most likely diagnosis is
    A. chronic lymphocytic leukemia
    B. Mycosis fungoides
    C. hairy cell leukemia
    D. acute lymphoblastic leukemia
    E. chronic myeloid leukemia
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  36. A patient presents with multiple plaque skin lesions. A punch biopsy of a skin lesion shows these histopathologic findings. The most likely diagnosis is
    A. eosinophilic granuloma
    B. Sezary syndrome
    C. Mycosis fungoides
    D. basal cell carcinoma
    E. psoriasis
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  37. This lymph node biopsy displays histologic features consistant with
    A. a low grade non Hodgkin's lymphoma
    B. a high non Hodgkin's lymphoma
    C. Hodgkin's disease
    D. metastatic carcinoma
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  38. This peripheral blood smear is from an elderly patient with a complaint of fatigue. The WBC's are predominantly: *(CLL = chronic lymphocytic leukemia) **(ALL = acute lymphoblastic leukemia) ***(inf. mono. = infectious mononucleosis)
    A. mature lymphocytes, suggestive of CLL*
    B. immature blasts, suggestive of ALL**
    C. irregular lymphocytes, suggestive of Sezary syndrome
    D. reactive lymphocytes, suggestive of inf. mono.***
    E. plasma cells, suggestive of multiple myeloma
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  39. This bone marrow aspirate displays blasts with prominant cytoplasmic vacuolation, suggestive of Burkitt's leukemia. The most likely cytogenetic abnormality is
    A. hyperdiploidy
    B. t[9,22]
    C. t[8,14]
    D. deletion short arm of 5
    E. t[14,18]
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  40. This bone marrow aspirate is from a patient with leukemia. A PAS stain was done, and the result is shown in the slide. The findings support a diagnosis of
    A. chronic myeloid leukemia
    B. chronic lymphocytic leukemia
    C. acute myeloid leukemia
    D. acute lymphoblastic leukemia
    E. hairy cell leukemia