NCBI Conserved Domain Database
PubMed Nucleotide Protein Structure CDD Taxonomy Help?
CD: pfam00042.11, Globin, Query added PSSM-Id: 25370 Source: Pfam[US], Pfam[UK]
Description: Globin.
Taxa:  cellular organisms References: 4 Pubmed Links Related: COG1017
Status: Alignment from source Created: 12-Dec-2003
Aligned: 77 rows PSSM: 139 columns Representative: Consensus
Proteins: [Click here for CDART summary of Proteins containing pfam00042]
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                      10        20        30        40        50        60
              ....*....|....*....|....*....|....*....|....*....|....*....|
consensus   1 QKALVKASWGKVKG----NREELGAEILARLFKAYPDTKAYFPKFgDLSTADALKSSPKF 56
query       7 DKTNVKAAWGKVGA----HAGEYGAEALERMFLSFPTTKTYFPHF------DLSHGSAQV 56
1ASH        4 TRELCMKSLEHAKVdtsnEARQDGIDLYKHMFENYPPLRKYFKSR-EEYTAEDVQNDPFF 62
1HDA_A      6 DKGNVKAAWGKVGG----HAAEYGAEALERMFLSFPTTKTYFPHF-DLS-----HGSAQV 55
1JEB_A      7 ERTIIVSMWAKIST----QADTIGTETLERLFLSHPQTKTYFPHF-DLH-----PGSAQL 56
gi 122319   6 DKKLIQQIWGKLGG----AEEEIGADALWRMFHSYPSTKTYFPHF-DLS-----QGSDQI 55
gi 122300   7 EKALVVGLCGKISG----HCDALGGEALDRLFASFGQTRTYFSHF-DLS-----PGSADV 56
gi 122329   7 DRATVRALWKKMGS----NVGVYATEALERMFLGFPSTTTYFLHL-DLS-----LGSTQV 56
gi 122274   6 DKNHIRAIWGHVDN----NPEAFGVEALTRLFLAYPATKTYFAHF-DLN-----PGSAQI 55
gi 122284   7 DKKHIKAIMPSIAA----HGDKFGGEALYRMFLVNPKTKTYFPTF-DFH-----HNSKQI 56

                      70        80        90       100       110       120
              ....*....|....*....|....*....|....*....|....*....|....*....|
consensus  57 KAHGKKVLGALGEAVKHLDDDGDLKAALAKLGARHAKRG-HVDPANFKLFGEALLVVLAE 115
query      57 KGHGKKVADALTNAVAHVDDMPN---ALSALSDLHAHKL-RVDPVNFKLLSHCLLVTLAA 112
1ASH       63 AKQGQKILLACHVLCATYDDRETFNAYTRELLDRHARDHvHMPPEVWTDFWKLFEEYLGK 122
1HDA_A     56 KGHGAKVAAALTKAVEHL--D-DLPGALSELSDLHAHKL-RVDPVNFKLLSHSLLVTLAS 111
1JEB_A     57 RAHGSKVVAAVGDAVKSI--D-DIGGALSKLSELHAYIL-RVDPVNFKLLSHCLLVTLAA 112
gi 122319  56 RGHGKKVVAALSNAIKNL--D-NLSQALSELSNLHAYNL-RVDPVNFKFLSQCLQVSLAT 111
gi 122300  57 KRHGGKVLSAIGEAAKHI--D-SMDQALSKLSDLHAYNL-RVDPGNFQLLSHCIQAVLAA 112
gi 122329  57 KAHGQKVADALTLAVEHL--E-DLPRALSALRHRHVREL-RVDPASFQLLGHCLLVTPAR 112
gi 122274  56 KAHGKKVVDALTQAVNNL--D-DIPDALAKLADLHAEKL-RVDPVNFGLLGHCILVTIAA 111
gi 122284  57 SAHGKKVVDALNEASNHL--D-NIAGSLSKLSDLHAYDL-RVDPGNFPLLAHNILVVVAM 112

                     130       140
              ....*....|....*....|....*
consensus 116 HLG-EFTPEVKAAWDKALDVVADAL 139
query     113 HLPaEFTPAVHASLDKFLASVSTVL 137
1ASH      123 KT--TLDEPTKQAWHEIGREFAKEI 145
1HDA_A    112 HLpsDFTPAVHASLDKFLANVSTVL 136
1JEB_A    113 RFpaDFTAEAHAAWDKFLSVVSSVL 137
gi 122319 112 RLgkEYSPEVHSAVDKFMSAVASVL 136
gi 122300 113 HFpaDFTPQCQAAWDKFLAAVSAVL 137
gi 122329 113 HFpgDFSPTLHASLVKFLSHVISAL 137
gi 122274 112 HNhgPLKADVALSMDKFLTKVAKTL 136
gi 122284 113 NFpkQFDPATHKALDKFLATVSSVL 137

Citing CDD: Marchler-Bauer A, Anderson JB, DeWeese-Scott C, Fedorova ND, Geer LY, He S, Hurwitz DI, Jackson JD, Jacobs AR, Lanczycki CJ, Liebert CA, Liu C, Madej T, Marchler GH, Mazumder R, Nikolskaya AN, Panchenko AR, Rao BS, Shoemaker BA, Simonyan V, Song JS, Thiessen PA, Vasudevan S, Wang Y, Yamashita RA, Yin JJ, Bryant SH (2003), "CDD: a curated Entrez database of conserved domain alignments", Nucleic Acids Res. 31: 383-387

 


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